Abstract
This prospective study examined the influence of long-term amiodarone therapy on the parameters of the signal-averaged ECG and their relation to simultaneously derived Holter monitoring data. For this purpose, 23 patients with angiographically confirmed dilated cardiomyopathy or coronary heart disease and high-grade ventricular arrhythmias, in whom an average of four class I antiarrhythmic drugs had proven ineffective, were stabilized on amiodarone. Before the beginning of therapy, as well as after 2 months and, subsequently, every 3 months, a resting ECG, a signal-averaged ECG by Simson's method, and Holter monitoring were performed. Compared to the initial measurement, we found a significant increase in the duration of the total filtered QRS complex from an average of 114 ± 24 ms to 127 ± 35 ms, while the change in voltage did not reach the significance level. The incidence of late potentials remained largely constant under amiodarone; 10 patients showed a constant late potential, 12 patients had no late potential, and one patient with coronary heart disease developed a new late potential. In the long-term follow-up, we ascertained a relatively high responder rate under amiodarone between 41% and 81%. No relation could be detected between the results of the signal-averaged ECG and those of 24-h Holter monitoring.
| Original language | English |
|---|---|
| Pages (from-to) | 187-193 |
| Number of pages | 7 |
| Journal | Zeitschrift fur Kardiologie |
| Volume | 80 |
| Issue number | 3 |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- Amiodarone
- Holter monitoring
- Late potentials
- Signal-averaged ECG
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Goedel-Meinen, L., Hofmann, M., Schmidt, G., Maier-Rudolph, W., Barthel, P., Schrag, A., Baedeker, W., & Blomer, H. (1991). The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring. Zeitschrift fur Kardiologie, 80(3), 187-193.
Goedel-Meinen, L. ; Hofmann, M. ; Schmidt, G. et al. / The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring. In: Zeitschrift fur Kardiologie. 1991 ; Vol. 80, No. 3. pp. 187-193.
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title = "The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring",
abstract = "This prospective study examined the influence of long-term amiodarone therapy on the parameters of the signal-averaged ECG and their relation to simultaneously derived Holter monitoring data. For this purpose, 23 patients with angiographically confirmed dilated cardiomyopathy or coronary heart disease and high-grade ventricular arrhythmias, in whom an average of four class I antiarrhythmic drugs had proven ineffective, were stabilized on amiodarone. Before the beginning of therapy, as well as after 2 months and, subsequently, every 3 months, a resting ECG, a signal-averaged ECG by Simson's method, and Holter monitoring were performed. Compared to the initial measurement, we found a significant increase in the duration of the total filtered QRS complex from an average of 114 ± 24 ms to 127 ± 35 ms, while the change in voltage did not reach the significance level. The incidence of late potentials remained largely constant under amiodarone; 10 patients showed a constant late potential, 12 patients had no late potential, and one patient with coronary heart disease developed a new late potential. In the long-term follow-up, we ascertained a relatively high responder rate under amiodarone between 41% and 81%. No relation could be detected between the results of the signal-averaged ECG and those of 24-h Holter monitoring.",
keywords = "Amiodarone, Holter monitoring, Late potentials, Signal-averaged ECG",
author = "L. Goedel-Meinen and M. Hofmann and G. Schmidt and W. Maier-Rudolph and P. Barthel and A. Schrag and W. Baedeker and H. Blomer",
year = "1991",
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Goedel-Meinen, L, Hofmann, M, Schmidt, G, Maier-Rudolph, W, Barthel, P, Schrag, A, Baedeker, W & Blomer, H 1991, 'The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring', Zeitschrift fur Kardiologie, vol. 80, no. 3, pp. 187-193.
The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring. / Goedel-Meinen, L.; Hofmann, M.; Schmidt, G. et al.
In: Zeitschrift fur Kardiologie, Vol. 80, No. 3, 1991, p. 187-193.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring
AU - Goedel-Meinen, L.
AU - Hofmann, M.
AU - Schmidt, G.
AU - Maier-Rudolph, W.
AU - Barthel, P.
AU - Schrag, A.
AU - Baedeker, W.
AU - Blomer, H.
PY - 1991
Y1 - 1991
N2 - This prospective study examined the influence of long-term amiodarone therapy on the parameters of the signal-averaged ECG and their relation to simultaneously derived Holter monitoring data. For this purpose, 23 patients with angiographically confirmed dilated cardiomyopathy or coronary heart disease and high-grade ventricular arrhythmias, in whom an average of four class I antiarrhythmic drugs had proven ineffective, were stabilized on amiodarone. Before the beginning of therapy, as well as after 2 months and, subsequently, every 3 months, a resting ECG, a signal-averaged ECG by Simson's method, and Holter monitoring were performed. Compared to the initial measurement, we found a significant increase in the duration of the total filtered QRS complex from an average of 114 ± 24 ms to 127 ± 35 ms, while the change in voltage did not reach the significance level. The incidence of late potentials remained largely constant under amiodarone; 10 patients showed a constant late potential, 12 patients had no late potential, and one patient with coronary heart disease developed a new late potential. In the long-term follow-up, we ascertained a relatively high responder rate under amiodarone between 41% and 81%. No relation could be detected between the results of the signal-averaged ECG and those of 24-h Holter monitoring.
AB - This prospective study examined the influence of long-term amiodarone therapy on the parameters of the signal-averaged ECG and their relation to simultaneously derived Holter monitoring data. For this purpose, 23 patients with angiographically confirmed dilated cardiomyopathy or coronary heart disease and high-grade ventricular arrhythmias, in whom an average of four class I antiarrhythmic drugs had proven ineffective, were stabilized on amiodarone. Before the beginning of therapy, as well as after 2 months and, subsequently, every 3 months, a resting ECG, a signal-averaged ECG by Simson's method, and Holter monitoring were performed. Compared to the initial measurement, we found a significant increase in the duration of the total filtered QRS complex from an average of 114 ± 24 ms to 127 ± 35 ms, while the change in voltage did not reach the significance level. The incidence of late potentials remained largely constant under amiodarone; 10 patients showed a constant late potential, 12 patients had no late potential, and one patient with coronary heart disease developed a new late potential. In the long-term follow-up, we ascertained a relatively high responder rate under amiodarone between 41% and 81%. No relation could be detected between the results of the signal-averaged ECG and those of 24-h Holter monitoring.
KW - Amiodarone
KW - Holter monitoring
KW - Late potentials
KW - Signal-averaged ECG
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Goedel-Meinen L, Hofmann M, Schmidt G, Maier-Rudolph W, Barthel P, Schrag A et al. The influence of amiodarone on data of the signal-averaged ECG and Holter monitoring. Zeitschrift fur Kardiologie. 1991;80(3):187-193.
