Related Papers
Endocrine
Accuracy of Doppler assessment of the uterine arteries in healthy girls for the diagnosis of pubertal onset
2021 •
Siqueira Lucena
Ultrasound in Obstetrics and Gynecology
Pelvic sonography and uterine artery color Doppler analysis in the diagnosis of female precocious puberty
2002 •
Lorenzo Iughetti
Ultrasound in Obstetrics and Gynecology
Pelvic ultrasound and color Doppler findings in different isosexual precocities
2003 •
Lorenzo Iughetti
Ultrasound in Obstetrics and Gynecology
Female precocious puberty, obesity and polycystic-like ovaries
2005 •
Alessandro Genazzani
Acta Bio Medica : Atenei Parmensis
The role of pelvic ultrasound for the diagnosis and management of central precocious puberty: An update
2021 •
Giuseppe Raiola
Sexual precocity refers to the appearance of physical and hormonal signs of pubertal development at an earlier age. It may be considered as the expression of secondary sexual characteristics prior to the pubertal age in central precocious puberty (CPP), which is gonadotropin-dependent, early maturation of the entire hypothalamic-pituitary-gonadal (HPG) axis occurs, with the full spectrum of physical and hormonal changes of puberty. True precocious puberty in girls must also be distinguished from premature thelarche (PT), usually with breast development before the age of 3 years, and premature pubarche (PA), with the isolated development of pubic hair. These conditions are not usually associated with accelerated growth rate or advancement in bone age. Clinical, laboratory and instrumental evaluations are necessary for the diagnosis. Pelvic ultrasound could serve as a complementary tool for the diagnosis, treatment and follow-up of CPP. The interpretation of clinical, laboratory and s...
European Journal of Endocrinology
Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche
2006 •
Liat Devries
Objective: To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. Design: Prospective. Methods: One hundred and three girls referred consecutively for evaluation of breast budding before age 8 years underwent physical examination, GnRH stimulation test, bone age assessment, and transabdominal pelvic ultrasound. The diagnosis of PP or PT was based on clinical judgment. The clinical, laboratory, and ultrasound data of the PP and PT groups were compared. Results: Eighty-one girls were diagnosed with PP and 22 with PT. Significant differences in most of the uterine and ovarian measurements were found between the groups. On logistic regression analysis, bone age standard deviation score, uterine transverse diameter, and uterine volume were the most significant variables predicting PP. Comparison of 3...
Archives of endocrinology and metabolism
Central precocious puberty: revisiting the diagnosis and therapeutic management
2016 •
Ângela Spinola-Castro
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty. Measurement of basal and stimulated LH levels remains challenging, considering that the levels are not always in the pubertal range at baseline, short-acting GnRH is not readily available in Brazil, and the cutoff values differ according to the laboratory assay. When CPP is su...
Blood transfusion = Trasfusione del sangue
Clinical and laboratory characteristics of children positive for antiphospholipid antibodies
2011 •
Ulrich Finckh
BACKGROUND: It is difficult to estimate the actual prevalence of antiphospholipid syndrome (APS) in the paediatric population since there are no standardised criteria. We aimed to assess clinical and laboratory characteristics of a cohort of children positive for antiphospholipid antibodies (aPL) to contribute to the understanding of the heterogeneous aPL-related features in childhood. MATERIALS AND METHODS: Forty-four patients with prolonged activated partial thromboplastin time were enrolled and assigned to group I ("transiently positive") or group II ("persistently positive"), based on the detection of elevated aPL plasma levels [lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) antibodies] on, respectively, one or more occasions, at least 12 weeks apart, by standard procedures. The clinical history and symptoms of all patients were recorded. RESULTS: Thirty-three (75%) patients were assigned to group I, while the other 1...
Significance of pelvic ultrasonographic examinations in girls with pubertal precocity and premature thelarche before and after GnRH-analogues treatment
2011 •
Monica Martina
Human Reproduction
GnRH agonist treatment in girls with precocious puberty does not compromise post-pubertal uterine size
2006 •
Liat Devries
